9/11/2023 0 Comments Bruker apex3As part of our ongoing studies, the title compound was synthesized and characterized by X-ray diffraction. Our previous work shows that the pyrrole moiety is an excellent hydrogen bond donor, and there exist different weak interactions in the crystals of its derivaties. DiscussionĬocrystals are an important class of crystalline materials, which can enhance physicochemical properties of drugs such as solubility and bioavailability. The hydrogen atoms were placed at calculated positions and refined as riding atoms with isotropic displacement parameters. The resulting solution was left in air for a few days, yielding colorless block-shaped crystals. The mixture was stirred for 1 h under refluxing. AtomĮthyl 5-formyl-2,4-dimethylpyrrole-3-carboxylate (0.390 g, 2 mmol) and thiosemicarbazide (0.091 g, 1 mmol) were dissolved in acetone (10 mL). Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å 2).
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